Frequently Asked Questions
No. Clevor is only approved for use in dogs.
No. The active ingredient in Clevor is ropinirole.
Ropinirole is a full dopamine agonist with selectivity for the dopamine D2-like receptor family. Ropinirole induces vomiting by activating the D2-like receptors in the chemoreceptor trigger zone, located in the area postrema, which transmits the information to the vomiting center to trigger vomiting.
For more information, download the full prescribing information.
No. Clevor is an eye drop for the induction of vomiting in dogs. It does not treat eye conditions.
In a clinical field study with 100 dogs in the Clevor group, 86% vomited after a single dose. The median time to vomit was 12 minutes (range: 3 to 37 minutes).1
The number of eye drops administered is determined by the body weight of the dog. If the dog does not vomit within 20 minutes of the first dose, then a second dose may be administered.
For complete dosage and administration instructions, see the package insert or download the prescribing information.
| Body weight in kilograms | Body weight in pounds | Total number of eye drops | Example administration |
| 1.8 – 5 | 4 – 11.1 | 1 | 1 drop into either left or right eye |
| 5.1 – 10 | 11.2 – 22.1 | 2 | 1 drop each eye |
| 10.1 – 20 | 22.2 – 44.1 | 3 | 2 drops in one eye and 1 drop in the other eye |
| 20.1 – 35 | 44.2 – 77.2 | 4 | 2 drops in each eye |
| 35.1 – 60 | 77.3 – 132.3 | 6 | An initial dose of 2 drops in each eye, followed 2 minutes later by 1 drop in each eye |
| 60.1 – 100 | 132.4 – 220.5 | 8 | An initial dose of 2 drops in each eye, followed 2 minutes later by 2 drops in each eye |
If the dog does not vomit within 20 minutes of the first dose, then a second dose may be administered. This second dose is the same number of drops as the first dose.
For technical assistance, contact Vetoquinol USA at 1-800-267-5707 or visit www.vetoquinolusa.com.
In a laboratory study, the safety of Clevor was tested at up to 5 times the labeled dose. In addition to vomiting, systemic effects of Clevor included: retching, salivation, hunched posture, tremors, labored breathing, lethargy, ventral and lateral recumbency, transient tachycardia, transient decrease in indirect systolic blood pressure (but not less than 125 mmHg), and a dose dependent decrease in body temperature (although all temperatures remained within normal limits). Local ocular effects of Clevor included ocular discharge, hyperemia, conjunctival erythema, blepharospasm, ptosis, third eyelid elevation, and positive corneal fluorescein staining.
All Clevor-related observations resolved within 6 hours post dosing. For more information, download the full prescribing information. To report suspected adverse events, call 1-800-835-9496.
To stop protracted vomiting, administer metoclopramide (a dopamine D2 antagonist) at a dose of 0.5 mg/kg intravenously (IV) or subcutaneously (SQ). Metoclopramide also decreases the prevalence of most Clevor-associated clinical signs.
For more information, download the full prescribing information.
Clevor is not for use in humans.
Wear gloves and protective eye wear when handling or administering this product to prevent accidental exposure. In case of accidental eye, oral, or skin exposure, flush with water. If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing. Remove contaminated clothing. Ropinirole is a dopamine agonist. Seek medical attention if accidental exposure occurs and show the package insert or label to the physician.
Clevor is not a controlled substance.
Clevor is available by prescription only and should be administered by veterinary personnel. Veterinary personnel are required to assess the patient for contraindications related to the induction of vomiting based on the substance(s) ingested, timing, and current clinical signs. Veterinary staff ensure the safe and effective use of the drug, then monitor for possible adverse reactions or clinical complications of the case.
Clevor is FDA approved safe and effective when used as indicated on the product label.
Do not use in dogs with central nervous system depression or seizures. Clevor should not be administered in cases with corneal ulceration, ocular irritation, or ocular injury. Do not use when there is a known sensitivity to ropinirole or the inactive ingredients. Adverse reactions may include: transient mild or moderate hyperemia of the eye, ocular discharge, protrusion of the 3rd eyelid and blepharospasm, transient mild lethargy, and increased heart rate.
For more information, download the full prescribing information.
Clevor has a shelf life of 3 years from date of manufacture when unopened and kept inside the sealed aluminum foil pouch.
In 2024, the U.S. Food & Drug Administration granted a 12-month expiration extension for Clevor after extensive product stability testing. Boxes of Clevor with the lot number EM099, bearing an expiration date of 8/31/2025, now have an extended expiration date of 8/31/2026. For all other lots, refer to the expiration date printed on the box.
Each box of Clevor contains five, single-use droppers packed in individual aluminum foil pouches. Unopened pouches will remain effective even if your practice doesn’t frequently see emergencies that require induction of emesis. Once opened, the dropper should be disposed of after 30 minutes.
All Vetoquinol products come with a 100% satisfaction guarantee. If you’re ever disappointed, let us know by first contacting your Vetoquinol Territory Manager or by calling 1-800-267-5707.
Clevor is available from a licensed veterinarian and should be administered by veterinary personnel. Veterinarians can contact their preferred distributor representative, Vetoquinol Territory Manager, or by calling 1-800-267-5707.
- Suokko, M., Saloranta, L., Lamminen, T., Laine, T., Elliott, J. (2020) Ropinirole eye drops induce vomiting effectively in dogs: A randomised, double-blind, placebo-controlled clinical study. Veterinary Record, Mar 7;186(9):283.
